The Succinate Receptor SUCNR1 Resides at the Endoplasmic Reticulum and Relocates to the Plasma Membrane in Hypoxic Conditions

The GPCR SUCNR1/GPR91 exerts proangiogenesis upon stimulation with the Krebs cycle metabolite succinate.GPCR signaling depends on the surrounding environment and intracellular localization through location bias.Here, we show by microscopy and by cell fractionation that in neurons, SUCNR1 resides at the endoplasmic reticulum (ER), while being fully

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Eclampsia An Obstetric Disaster

Eclampsia has been graded as fatal and dreadful disease even before Christ and is the important cause of maternal and Doll house furniture perinatal mortality in developed and developing countries.Severe morbidity associated with eclampsia include placental abruptio, cerebral haemorrhage, cortical blindness, renal failure, disseminated intravascula

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